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ELEVATING TOMORROW’S STANDARD OF CANCER CARE TODAY

 

WELCOME TO ABALYTICS ONCOLOGY

10 Million people die from cancer every year. It remains the cause of every sixth death. At Abalytics Oncology, our vision is to redefine the standard for drug development in the 21st century.

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Core Values

How do you approach drug development in the age of artificial intelligence? Where do you choose to focus? At Abalytics Oncology, three simple values drive every action we take:

Overall survival

Quality of life

Greater Understanding

Strategic Missions for 2025 and Beyond

01

Develop best-in-class CTLA-4 targeting bispecific antibodies

02

Develop next-generation multispecific therapies with finely tuned dynamics

03

Build data model and system integrations to solve immune dysregulation

Abalytics Stands for Antibody Data Analytics

Abalytics Intelligence

Sequences

Clinical Trials

Structures

Publications

Patents

Biomarkers

Companies

Technologies

Investments

Code

Real-world information, in real-time

Artificial Intelligence generates infinite options, which human intelligence evolved to constrain.

Abalytics Algorithms

Target selection

Antibody design

Lead identification

Translational modeling

Treatment optimization

Resource allocation

Abalytics Pipeline Programs

Bispecific oncology therapies

Bispecific immune cell modulators

Bispecific pMHC targeted TCR mimetics

We use computational antibody design and biomolecular engineering to develop better treatments

Pipeline Programs

Program

Discovery

IND-Enabling Studies

Status

CTLA-4 targeting multi-specific antibodies with unique dynamics

ABAO5

PD-1 / CTLA-4 / VEGF

Ready for CMC

ABAO4

CTLA-4 / VEGF

Ready for CMC

ABAO3

CTLA-4 / PD-1

Available to Partner

pMHC-targeted bispecific TCR mimetic

ABAO6

pMHC / CD3

R&D

Bispecific targeted degrader

ABAO7

XX / YY

R&D

Our understanding of antibody therapeutics continues to evolve, but molecular dynamics remain a black box

X

INPUT
(1017) molecules with an identical coded sequence are dosed in a human you love…
(1017) molecules with an identical coded sequence are dosed in a human you love…
INPUT

X

2nd+ order PD interactions

  • Blockade
  • Internalization
  • Recycling
  • Degradation
  • Protein-protein
  • Protein-cell
  • Cell-cell
  • …

Y = F(X)

OUTPUT
  • Objective Response
  • Treatment Related Adverse Events
  • Overall Survival

SEQUENCE

STRUCTURE

PATIENTS SPECIFIC OUTCOMES

DYNAMICS

With only the first prediction problem “solved”, how can we achieve the outcomes we want?

ABAO3: A next generation PD-1 / CTLA-4 bispecific antibody enhances safety and efficacy with PD-1 degradation and CTLA-4 recycling

Features

Opportunity

CTLA-4 Recycling

Minimize Toxicity

PD-1 Degradation

Maximize Efficiency

Validated Epitopes

Minimize Uncertainty

ABA03

PD-1 / CTLA-4 BsAb

  • Ipilimumab and Tremelimumab validate anti-CTLA4 development in solid tumors
  • Robust Overall Survival across tumor types limited by the severe immune related Adverse Events (irAE) of legacy approaches
  • Novel insights demonstrate the feasibility of delivering anti-CTLA4 efficacy without the toxicity

Abalytics Oncology next generation antibody-based pMHC targeted therapies aim to distinguish cancer from self

The information age has unlocked new insights into where cancer appears that we can target

Abalytics computational design offers advantages over existing TCR  and TCR mimetic approaches

Modular next-generation antibody-based formats offer validated options to optimize safety, efficacy, and developability

Our Team

Shay Paintal

Chief Executive Officer

Shay combines a track record of successful computational antibody design and development with a decade of experience founding data analytics ventures. He is credited with the invention of Omoprubart and has executed on over 20 other drug development programs, including TY027. Before formalizing a system for computational antibody design in the Sasisekharan Lab at MIT’s Koch Institute for Integrative Cancer Research, Shay spent a decade building technology solutions for public and private sector clients exploring practical applications of artificial intelligence. An ex-Deloitte Systems Integration consultant, Shay holds a Bachelor of Science in 
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Manish Potti

Chief Business Officer

Manish has a track record of execution in the biopharmaceutical industry. He was the Chief Business Officer of Shinkei Therapeutics, a CNS focused company. He was previously the President and co-founder of Innogenix Pharmaceuticals. At Innogenix, Manish took a brownfield project through FDA facility approval, directed the R&D strategy, in-licensed assets, and grew the revenue to a stable base. He was also the head of business development of Epic Pharma, where he led the sale process of the company to Humanwell Healthcare of China in 2016. Since 2016, he has been actively investing and managing portfolio companies in health care
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Joyson Karakunnel, MD, MSC, FACP

Board Member

Joyson Karakunnel is an experienced medical oncologist and hematologist with over 20 years of experience in drug development both in academia and industry in multiple therapeutic areas and drug modalities. He is an independent consultant for private and public biotechs and VC/PE firms. He serves on the BOD for Primevax and Precision Biologics. He has served as an advisor at the Parker Institute for Cancer immunotherapy. He was CMO at iTeos Therapeutics, Innate Pharma, Tizona Therapeutics and was part of the founding team for Trishula Therapeutics. He has held leadership positions at Arcus Biosciences and Medimmune/Astrazeneca where 
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Toni Choueiri, MD

Advisor: Scientific and Clinical

Dr. Toni K. Choueiri is the Director of the Lank Center for Genitourinary (GU) Oncology at Dana-Farber Cancer Institute, co-leader of the Kidney Cancer Program at Dana-Farber/Harvard Cancer Center, and the Jerome and Nancy Kohlberg Chair and Professor of Medicine at Harvard Medical School. He is the Medical Director, International Strategic Initiatives at Dana-Farber and past President of the Dana-Farber Medical Staff (2016-2018). Dr. Choueiri is an elected member of the American Society of Clinical Investigation (ASCI). In addition, he is an Aresty Scholar from the Wharton School of Business at the University of Pennsylvania. 
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F. Stephen Hodi, MD

Advisor: Scientific and Clinical

Stephen Hodi, MD, is a medical oncologist and principal investigator at Dana-Farber Cancer Institute and professor of medicine at Harvard Medical School. He is director of the Melanoma Center and the Center for Immuno-Oncology at Dana-Farber/Brigham and Women’s Cancer Center. Hodi earned his medical degree at Cornell University Medical College, did his postdoctoral training in internal medicine at the University of Pennsylvania, and completed a medical oncology fellow at Dana-Farber, joining the faculty in 1998. An internationally recognized leader in developing immune therapy and melanoma therapeutics, Hodi is particularly known for the clinical 

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Bernard A. Fox, PhD

Advisor: Translational Science and Development

Bernard A. Fox, PhD, is Chair of the World Immunotherapy Council (WIC) and past President of the Society for Immunotherapy of Cancer (SITC). He is the Harder Family Chair for Cancer Research, Member and Chief of the Laboratory of Molecular and Tumor Immunology, Earle A. Chiles Research Institute (EACRI), Providence Cancer Institute. He is also Founder, President, and Chief Executive Officer of UbiVac, a clinical stage immunotherapy company with disruptive cancer vaccine technology that contains shared canonical and recently described non-canonical alternative cancer neoantigens. Prior to joining the EACRI, Bernie spent 5 years in Dr. Steven A. Rosenberg’s laboratory 
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Sherry La Porte, PhD

Advisor: Antibody Engineering, Development, and Strategy

Sherry LaPorte is a biotech veteran with vast experience in antibody engineering and development. As Director of Biotherapeutics Engineering at Janssen, she led efforts in multi-specific antibody design and ADC development. At CytomX Therapeutics, she focused on masking technologies and advancing innovative antibody platforms, and at Pfizer, she contributed to the development of clinical candidates across oncology, immunology, and neurodegeneration. Earlier in her career, Sherry conducted postdoctoral research at Stanford and UCSF, where she focused on molecular biology and structural immunology, building a strong foundation for translating sequence-level insights into clinical-stage therapeutics.

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Connect with us about reshaping the future of cancer care today.

© 2024 Abalytics Oncology. ALL RIGHTS RESERVED

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Shay combines a track record of computational antibody design and development with a decade of experience implementing data analytics systems across diverse healthcare settings. He is credited with the invention of Omoprubart and has executed on over 15 other cutting edge drug development programs, including TY027. Before formalizing a system for computational antibody design in the Sasisekharan Lab at MIT’s Koch Institute for Integrative Cancer Research, Shay developed technology solutions for public and private sector clients exploring practical applications of artificial intelligence. An ex-Deloitte Systems Integration consultant, Shay holds a Bachelor of Science in Chemical and Biomolecular Engineering from Johns Hopkins University.

Manish has a track record of execution in the biopharmaceutical industry. He was the Chief Business Officer of Shinkei Therapeutics, a CNS focused company. He was previously the President and co-founder of Innogenix Pharmaceuticals. At Innogenix, Manish took a brownfield project through FDA facility approval, directed the R&D strategy, in-licensed assets, and grew the revenue to a stable base. He was also the head of business development of Epic Pharma, where he led the sale process of the company to Humanwell Healthcare of China in 2016. Since 2016, he has been actively investing and managing portfolio companies in health care. Manish has overseen R&D, regulatory, commercial, and manufacturing in his career. He began his career in banking and as a trader at a hedge fund. Manish holds a Bachelor of Science in Molecular Biology from Johns Hopkins University, and a Master’s in Financial Engineering from New York University.

 

Joyson Karakunnel is an experienced medical oncologist and hematologist with over 20 years of experience in drug development both in academia and industry in multiple therapeutic areas and drug modalities. He is an independent consultant for private and public biotechs and VC/PE firms. He serves on the BOD for Primevax and Precision Biologics. He has served as an advisor at the Parker Institute for Cancer immunotherapy. He was CMO at iTeos Therapeutics, Innate Pharma, Tizona Therapeutics and was part of the founding team for Trishula Therapeutics. He has held leadership positions at Arcus Biosciences and Medimmune/Astrazeneca where he was involved in the approval for Imfinzi and Imjudo in monotherapy and combination settings. Prior to joining the pharmaceutical industry, he was an investigator in clinical trials at the NCI and team leader for the hematologic group at Walter Reed National Military Medical Center. He was an Associate Professor at the Uniformed Services University of the Health Sciences and medical reviewer at the FDA. He did his fellowship training in hematology and oncology at the National Cancer Institute and residency training at Overlook Hospital/UMDNJ. He was elected as a Fellow in the American College of Physicians (FACP). He completed his medical training at Annamalai University in India. He holds a Master’s of Pharmacology from the University of Maryland and is a member of Phi Beta Kappa. he holds an MBA from the Kelley School of Business.

Dr. Toni K. Choueiri is the Director of the Lank Center for Genitourinary (GU) Oncology at Dana-Farber Cancer Institute, co-leader of the Kidney Cancer Program at Dana-Farber/Harvard Cancer Center, and the Jerome and Nancy Kohlberg Chair and Professor of Medicine at Harvard Medical School. He is the Medical Director, International Strategic Initiatives at Dana-Farber and past President of the Dana-Farber Medical Staff (2016-2018). Dr. Choueiri is an elected member of the American Society of Clinical Investigation (ASCI). In addition, he is an Aresty Scholar from the Wharton School of Business at the University of Pennsylvania. Dr. Choueiri is interested in developing novel experimental therapies and biomarkers in GU malignancies as well as interest in liquid biopsies and markers of toxicity of systemic agents. His work has been published in journals such as the NEJM, Nature, Nature Medicine, Science, Journal of American Medical Association (JAMA), JAMA Oncology, The Lancet, Lancet Oncology, and Journal of Clinical Oncology. He lectures frequently throughout the United States and around the world. He has over 800 PubMed-indexed publications and is the lead investigator of multiple national and international phase I-III trials in GU cancers.

Stephen Hodi, MD, is a medical oncologist and principal investigator at Dana-Farber Cancer Institute and professor of medicine at Harvard Medical School. He is director of the Melanoma Center and the Center for Immuno-Oncology at Dana-Farber/Brigham and Women’s Cancer Center. Hodi earned his medical degree at Cornell University Medical College, did his postdoctoral training in internal medicine at the University of Pennsylvania, and completed a medical oncology fellow at Dana-Farber, joining the faculty in 1998. An internationally recognized leader in developing immune therapy and melanoma therapeutics, Hodi is particularly known for the clinical development of checkpoint inhibitors. He led the first human trial of ipilimumab, which blocks the CTLA-4 checkpoint, and later led the phase III registration trial, which was the first study to show a survival advantage for a melanoma drug, and which led to FDA approval of ipilimumab. The dramatic and long-lasting responses seen with this agent provided proof that reactivating the suppressed immune system of cancer patients could be enormously beneficial. Subsequently, Hodi has continued as a key investigator in the clinical development of the second family of checkpoint inhibitors, which block PD-1 and PD-L1. This work has not only changed the paradigm for treating melanoma but has also been applied to improve outcomes in many other malignancies, such as lung and kidney cancer. He has also led pioneering, investigator-initiated trials combining immune checkpoint blockade with cytokines and the first combination of immune checkpoint blockade with anti-angiogenesis agents. Hodi is also known for his work in treating KIT-mutated melanoma.

Bernard A. Fox, PhD, is Chair of the World Immunotherapy Council (WIC) and past President of the Society for Immunotherapy of Cancer (SITC). He is the Harder Family Chair for Cancer Research, Member and Chief of the Laboratory of Molecular and Tumor Immunology, Earle A. Chiles Research Institute (EACRI), Providence Cancer Institute. He is also Founder, President, and Chief Executive Officer of UbiVac, a clinical stage immunotherapy company with disruptive cancer vaccine technology that contains shared canonical and recently described non-canonical alternative cancer neoantigens. Prior to joining the EACRI, Bernie spent 5 years in Dr. Steven A. Rosenberg’s laboratory at the Surgery Branch, NCI, NIH. His undergraduate studies were at the University of Detroit and he received his PhD from Wayne State University. Dr. Fox maintains a faculty appointment at OHSU and membership in the NCI Knight Cancer Institute. Dr. Fox lectures widely, authored more than 200 papers and book chapters, has served or serves as a professor at universities in Germany, The Netherlands, China, and Taiwan, and as a member of review committees for the NIH, FDA, philanthropic, and governmental organizations in the USA, Europe, and Asia. In 2015, he received the Visionary/Legacy Award from SITC. In 2020 Dr. Fox received a SITC Team Science Award and the Melanoma Foundation Onlus Bridge Award, for outstanding and lifelong contributions to melanoma research. In 2022 he received SITC’s Tara Withington Public Service Award.